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Modafinil , a wakefulness-promoting agent that raises cortical catecholamines and was developed for narcolepsy, has the firmest evidence among prescription options used off-label, and it suits longer and more demanding work

British Journal of Haematology , 166(4), 496-513.

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However, an early deviation in the slope suggested a violation of the proportional hazards assumption in the first 12 months, although the stabilization afterward indicated the issue was not persistent over the full duration of the study

At que sejam realizados testes adequados em humanos, os usurios esto essencialmente se voluntariando como cobaias em um experimento no controlado com seus prprios corpos.